The severity of renal damage was related to the duration and amplitude of serum uric acid. In these patients, chronic hyperuricemia results in the deposition of urate crystals in the distal collecting duct and the renal interstitium, especially in the renal medulla and papillary region. In the course of a long period of time, the kidney can not only form a stone, but also accompanied by fibrosis, glomerulosclerosis, arteriosclerosis and arterial wall thickening.
Lowering blood uric acid can improve renal function
Elevated serum uric acid levels will have a greater impact on renal function, especially in the presence of chronic uric acid nephropathy onset, if not treated in time, to the late stage of the disease, the patient and society will cause a huge burden.
Some studies have found that lowering serum uric acid can improve renal function. Routine examination of blood uric acid is recommended for early detection of hyperuricemia. The diet of the patients with hyperuricemia should be based on low purine food, strictly control the intake of seafood, animal offal, concentrated broth and beer. Schedule for daily food 100g contained in purine content. In the case of hyperuricemia, the main type of food intake was to reduce the intake of type.
At the same time to change the way of life, according to the severity of the disease to consider the use of allopurinol, sodium bicarbonate and benzene bromine Malone and other drugs to reduce blood uric acid. Avoid drug application so that the blood uric acid increased, such as diuretics (especially thiazide), glucocorticoids, insulin, cyclosporine, tacrolimus, nicotine, pyrazinamide and nicotinic acid etc..
When the patient's renal function has been significantly reduced, can be controlled in the premise of the disease in the early diet and drug treatment. When patients with oliguria, edema and heart failure, should control the intake of salt and water. Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists, such as Kato Pury, perindopril and irbesartan, may also be used. These drugs can reduce proteinuria and inhibit inflammation of renal tissue, thereby delaying the decline of renal function.
Acute kidney injury is a common clinical syndrome, and its morbidity and mortality are high in china. It is reported that China has nearly 4 million people suffering from the disease every year, and the number of patients has been rising year by year. Kidney internal medicine experts pointed out that acute kidney injury and chronic kidney disease is treatable, as long as the regular physical examination, pay attention to the details of life, to a large extent can also be prevented.
With the increasingly high incidence of hypertension and diabetes, high difficulty and extensive surgery, drug abuse and environmental pollution, kidney disease has become a serious threat to human health, especially the epidemic, guide the public to kidney disease in high-risk population to prevent acute kidney injury has become increasingly urgent.
To prevent acute kidney injury should pay attention to the following points:
1. High risk groups should be a regular physical examination: experts said that the elderly, patients with kidney disease are high risk of acute kidney injury, including patients with underlying kidney disease is more likely to occur acute kidney injury. The most common underlying diseases are diabetes and hypertension. If there are people with these diseases, it is necessary to pay attention to check whether there is a problem with their kidneys. Experts suggest that high-risk groups or ordinary people to do regular regular physical examination, which should be routine urine. If abnormal urine routine, it is recommended to do a renal function test, and then do a B ultrasound.
2. Do not abuse drugs: in particular, to prevent the abuse of aminoglycoside antibiotics, such as gentamicin, non steroidal anti-inflammatory drugs, such as anti-inflammatory painkillers, as well as containing aristolochic acid composition of traditional Chinese medicine. Experts remind the majority of users, especially those with high risk of acute kidney injury, usually medication must be careful, if these drugs are prone to acute kidney injury.
3. Usually pay attention to the prevention of infection: avoid poisoning, such as bee venom, snake venom, mushroom, fish bile poisoning. On the one hand, some bacterial virus infection and poisoning itself can lead to kidney damage, on the other hand, the use of drugs for the treatment of infection may lead to kidney damage. Fever is sometimes caused by the use of antipyretic, a large number of sweat, dehydration, kidney perfusion can lead to acute kidney injury.
4. Pay attention to the daily diet: experts said that if you appear edema, urine volume and other circumstances should pay attention to control of drinking water. If you have heart failure, pulmonary edema and other symptoms to control diet. Patients with high blood pressure should also pay attention to low salt diet. In addition, we should also pay attention to nutrition intake.
5. Proper exercise, do not exercise too much: if you do not exercise at ordinary times, suddenly suddenly increase the amount of exercise, it is also likely to cause acute kidney injury. This is because of excessive exercise, resulting in muscle dissolution, myoglobin released into the blood in the muscle, the formation of crystals in the renal tubule, blocking the renal tubules, affecting the renal function, which lead to acute kidney injury
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