What is the cause of polycystic kidney disease
In recent years, the incidence of polycystic kidney disease continues to increase, the cause of polycystic kidney disease is the subject of my friends are interested in order to effectively prevent the onset of the disease, ie, is that we must first know the cause of polycystic kidney disease, then to please experts kidney hospital to tell you about it.
The exact cause of the disease remains unclear. Although most symptoms after only the adults, but in the fetus begins to form. Cyst origin in the renal tubules, its liquid nature varies with the site of origin, the cause of polycystic kidney disease originated in the proximal tubule, the cyst fluid components such as Na +, K +, Cl, H +, creatinine, urea and plasma is similar; causing the balloon to the distal end within the liquid of Na +, K + concentration is low, a high Cl, H +, creatinine and urea concentrations.
90% of ADPKD patients with abnormal gene on the short arm of chromosome 16 genes known ADPKD1, gene products is unclear. Many of the coding region of the gene has been elucidated by cloning, is expected in the near future, ADPKD1 polycystic kidney disease can be confirmed. Another 10% of patients with less abnormal gene on the short arm of chromosome 4 is located, called ADPKD 2 gene which encodes a product are not clear. Both groups of the onset of hypertension and appear to enter ages range from kidney failure.
Polycystic kidney disease in patients with abnormal capsule glomerular epithelial cell proliferation is one of the most remarkable ADPKD, and development are not fully developed or state, is highly suggestive of mature bacterial regulatory barriers, cells in an immature, thereby displaying a high proliferation. This abnormal cell transport is another important feature of PKD, the performance of cellular transport is closely related to the Na + K + ATP ase combinations of subunits, distribution and changes in the activity of expression; cell anomalies and changes in ion channel signaling transport. Abnormal proliferation of the extracellular matrix are the main features of PKD third. The research revealed that the cause of polycystic kidney disease: the involvement of these anomalies are associated with an activity of growth factor cells. But the links and ways not yet clear key exception. In summary, due to a genetic defect due to the growth of mesenchymal cells and the formation of abnormal variations, an important pathogenesis of disease oriented.
What diet polycystic kidney disease should pay attention to
The food is we all know, but there are still a lot of friends are not very aware of their eating habits, diet polycystic kidney disease many of my friends are asking the question, then this diet polycystic kidney disease should be careful I need regular. Us please experts kidney hospital to tell you, we want to help.
The amount of food is necessary, eat too much or too little are unfavorable physical rehabilitation. Such as hunger are undernourished; fullness is easy to hurt the stomach digestion, absorption and blood circulation disorders function; Many patients, renal cysts, polycystic kidney disease in patients with eating as much cold food cold, and easily hurt the stomach yang, eating hot Xin Wen allow the gastro accumulated heat, then there are flavors addicts partial , for a long time so easily hurt visceral.
Other Considerations - For multiple renal cystic disease, clinical practice, we emphasize the following aspects, polycystic kidney disease should pay attention to spicy food: such as pepper, alcohol, tobacco (including smoking liabilities), chocolate, coffee, fish, shrimp, crabs and other "hair thing", salty foods, especially marinated grilled meat, contaminated, such as unhealthy food, rotten leftovers, etc foods.
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