What should you pay attention to during the treatment of nephritis?
1. Active control of hypertension and reduced urinary protein
Hypertension and urinary protein is an important factor in accelerating
glomerulosclerosis and promoting deterioration of renal function. Active control
of hypertension and reduction of urinary protein are two important links.
Nephritis often sodium and water retention caused by capacity-dependent
hypertension, so hypertensive patients should limit salt (NaCl <6g / d);
optional thiazide diuretics, such as hydrochlorothiazide.
Ccr <30ml / min, the thiazide ineffective should use the loop diuretics,
but generally should not be too much, long-term use. ACEI or ARB in addition to
lower blood pressure, there are reduced urinary protein and delayed renal
function deterioration of the kidney protection for nephritis treatment of
hypertension and / or reduce the urinary protein of choice drug.
Usually to achieve the purpose of reducing urinary protein, the application
dose often need higher than the conventional antihypertensive dose. Renal
insufficiency in patients with ACEI or ARB to prevent hyperkalemia, serum
creatinine greater than 264μmol / L (3mg / d1) must be closely monitored serum
creatinine, serum potassium, to prevent side effects.
In addition to the above methods of controlling hypertension, we can also
combine the above methods together, or choose some β-blockers for treatment.
2. Limit the amount of protein and phosphorus in food
Renal insufficiency azotemia patients should limit the amount of protein and
phosphorus, the use of high-quality low-protein diet or add essential amino
acids or α-keto acid.
3. Glucocorticoids and cytotoxic drugs
In view of nephritis, including a variety of diseases, so whether the
application of drugs, should be treated differently. But the patient's normal
renal function or only mildly damaged, normal renal volume, pathological type of
light (such as mild mesangial proliferative glomerulonephritis, early membranous
nephropathy, etc.), more urine protein, such as no contravention can try,
invalid Gradually withdraw.
4. Anticoagulant, fibrinolytic and antiplatelet depolymerization drugs
Such drugs can inhibit fibrin formation, platelet aggregation, reduce
complement activity, but the effect is not sure.
5. To avoid aggravating the factors of kidney damage
Nephritis patients, in the usual life, but also pay more attention to living
habits, to avoid some of the infection or fatigue, which may lead to
deterioration of renal function.
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