What is hyperuricemia?

Uric acid nephropathy manifested as renal interstitial and renal tubular uric acid deposition, visible birefringence of the needle-like urate crystals, these crystals caused by infiltration around the mononuclear cells, leading to renal tubular epithelial cell necrosis, tubular atrophy, Luminal occlusion, interstitial fibrosis, and thus damage the kidney unit. The formation of tiny calcium in the collection tube allows the collection tube to expand and easily lead to secondary bacterial infections. The disease is divided into primary and secondary two categories. The basic nature of the original genetic, but the genetic way is not clear, more and more clinical data show that primary gout and obesity, essential hypertension, dyslipidemia, diabetes, insulin resistance is closely related.

Uric acid nephropathy in Europe and the United States the incidence rate of about 0.3%, the European Association for the analysis of dialysis end-stage renal failure caused by gout accounted for 0.6 to 1.%. In recent years, the Chinese people because of dietary protein and purine content of food intake increased, the incidence of gout increased.

Secondary hyperuricemia are more common in the following three cases

①, cell proliferative diseases, such as: leukemia, lymphoma, myeloma, erythrocytosis;

②, excessive cell damage: hemolysis, burn trauma, chemotherapy, radiotherapy, excessive exercise;

③, renal failure, ketoacidosis, pregnancy-induced hypertension syndrome, drugs, toxic agents lead to renal clearance to reduce uric acid.

Clinical manifestations of uric acid nephropathy

1. Renal manifestations

Arthritis, gout, gout nodules, hyperlipidemia, hypertension and heart failure. 2. Kidney damage performance: edema, proteinuria, high blood pressure, nocturia; kidney stones were low back pain, hematuria or urinary frequency, urgency, dysuria and fever.

Urinary acid nephropathy can have two kinds of kidney damage

① the formation of urinary tract stones; ② uric acid caused by renal parenchymal damage. These two kinds of kidney damage can also coexist, the clinical manifestations are the following three:

(1) chronic hyperuricemia

More common in middle-aged men. More associated with gouty arthritis or pain stone;

Urinary acid nephrotic syndrome urinary acid nephropathy early renal failure showed mild proteinuria, a small amount of red blood cells and urine concentration decreased; late high blood pressure, renal dysfunction, a few lead to uremia. Kidney can be seen within the medulla of radial needle-shaped uric acid crystals and chronic changes in renal interstitial inflammation.

(2) acute uric acid nephropathy

Acute onset, more common in bone marrow proliferative disease and malignant tumor radiotherapy, chemotherapy. Clinical manifestations of oliguria or even anuria, and rapid deterioration of renal function (ie, acute renal failure). Urine can be seen a lot of uric acid crystals and red blood cells. If not timely treatment, the condition continues to deteriorate, the patient eventually died of renal failure.

(3) uric acid stones

More asymptomatic, hematuria can occur, with or without renal colic, stones for light transmission, abdominal plain film and more display, often through the intravenous pyelography to be found. Urine composition is uric acid or its salts.

Uric acid nephropathy diet

1, easy to eat light digestible food, avoid seafood, beef, lamb, spicy spicy food, wine and all things such as spices, coffee, parsley and so on. 2, fresh vegetables and vegetables, the amount of fruit, proper drinking; eat all tonic, tonic and easy to lit food such as pepper, lychee, chocolate and so on.

3, all uric acid nephropathy patients disabled penicillin, streptomycin, gentamicin, Guanmutong and automatic immunization of the injection.

4, uric acid nephropathy should be defecation 2-3 times a day is appropriate; do not stay up all night, control sexual life; pay attention to rest, to avoid cold.

5, have taken hormones, should be based on specific circumstances under the guidance of physicians to reduce the amount of hormone and the number of times.

6, should avoid salt, limit the intake of protein food, less drinking water. Microscopic hematuria and those who should be lit more water, eat more apples, sugar, black sesame seeds, edible fungus and other food.

7, eat high potassium foods such as: bananas, citrus, potatoes, tomatoes, pumpkins, tea, soy sauce, monosodium glutamate; low blood potassium patients the opposite.

8, especially not eat animal offal, fish and crab clam, beer, mushrooms, beans, spinach.