Proteinuria is a typical symptom of nephropathy, but the number of leakage of urine protein and can not reflect the severity of nephropathy. Mild chronic kidney disease in patients with less leakage of urinary protein does not necessarily explain the renal pathological damage; a large number of proteinuria can not explain the serious pathological damage of kidney disease. Such as minor lesions of nephritis and mild mesangial proliferative glomerulonephritis, mild renal disease, but the daily amount of urine protein up to several grams or even ten grams.
In general, proteinuria is divided into selective proteinuria, nonselective proteinuria. Selective proteinuria, protein electrophoresis is characterized by a small molecular weight of the protein-based, such as albumin, α1 globulin, transferrin and γ globulin. Molecular weight of the larger protein, such as α2 globulin, fibrinogen, β-lipoprotein and other content less.
In the small lesions of nephropathy, mild mesangial proliferative glomerulonephritis, partial membranous nephropathy and early lesions of membranous proliferative glomerulonephritis and focal segmental sclerosing glomerulonephritis patients, showing multiple selective proteinuria, indicating a small network (kidney Small ball filter membrane) damage lighter.
Non-selective proteinuria, protein electrophoresis is characterized by macromolecules and small molecules of protein at the same time, indicating that small network (glomerular filtration membrane) damage is more serious.
Would like to ask, urinary protein loss of a large number of patients recover?
Kidney disease expert analysis, the number of protein loss, and the severity of the disease is not proportional to. Patients with mild glomerular lesions, urinary protein is not necessarily less, such as minor lesions of nephritis and mild mesangial proliferative glomerulonephritis, kidney lesions slightly, but the daily amount of urine protein up to several grams or even ten grams.
On the contrary, some focal sclerosis nephritis and crescentic
glomerulonephritis, the pathological damage is serious, but the daily amount of urine protein may be only a few grams. So the treatment is good or bad, mainly depends on the pathological type of kidney, damage and renal function.
In addition, we should also see whether the patient can cooperate with the doctor, whether attention to prevent the emergence of recurrent incentives (such as colds, fatigue, diarrhea, etc.), whether to adhere to treatment, whether to avoid the use of nephrotoxic drugs.
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