IgA Nephropathy

http://www.igancure.com/iga-nephropathy-basics/3846.htmlIgA glomerulonephritis on recurrent macroscopic or microscopic haematuria, glomerular mesangial cell proliferation and matrix, with wide IgA sedimentary features of primary glomerular disease.Berger, first described the disease in 1968, so it is also said Berger's disease.In addition, also known as IgA and IgG mesangial sedimentary membranous glomerulonephritis and IgA glomerulonephritis, etc.IgA nephropathy can also be interpreted as renal biopsy immunofluorescence examination glomerular mesangial area has large granular IgA sedimentary features of primary glomerular disease.
pathogenesis
Did not clarify the pathogenesis of the disease.Due to the disease in the patient's skin and liver can be detected IgA deposits, tips for systemic disease.Because in glomerular mesangial area and capillaries are granular IgA and C3 deposition, prompt the immune complex pathogenesis.The current study around the ability of antigen by mucous membrane and mucous membrane barrier exists defects;IgA structure are flawed and immune regulating function are flawed and other aspects.Early studies have prompted the disease by deposition of IgA is probably mucosa source sex.However in recent years, the study USES the technology of highly specific, confirmed that the disease is sedimentary IgA1, mainly system source sex, mainly produced by the bone marrow and the lymphatic system;Mucosal IgA2 source sex is mainly in liver source sex in the glomerular sclerosis of IgA deposits.In circulation in the disease patients also visible to the total IgA1 and contain higher immune complex of IgA1, increase in the number of plasma cells in the bone marrow to produce IgA1 and polymer is formed primarily.In this disease can be found in the kidney tissues of J chain, so the tip deposition of IgA is polymer;But that secrete piece is rare.However, the existing data can not be finalized IgA sediment source of the disease.


T helper cells differentiation and function
Many antigens, including a variety of viruses and a variety of foods in the disease patients of antigens detected in mesangial area, and is often accompanied by IgA1 deposition.These antigens antibodies are IgA1.Because the antibodies can also exist in normal cycle, the antigen specificity or characteristic
How to prevent the IgA nephropathy
1. Proper rest, avoid strenuous exercise, but in a stable condition, appropriate exercise is necessary.2. Increase the disease-resistant ability, avoid catch cold catch cold, reduce the chance of infection, once appear all sorts of infection, should be timely application of powerful antibiotics and early infection control.3. The prevention and treatment of IgA nephropathy diet: eating is given priority to with delicate, should eat more fruits, vegetables and high quality high protein food, ban acrimony, fat GanHou flavour, and mould products, preserved food, avoid alcohol.