Children with nephrotic syndrome causes and classification

Children with nephrotic syndrome is a massive proteinuria (24 hours urinary protein more than 3.5 grams) of hyperlipemia and varying degrees of clinical syndrome.Common cause can be made of primary glomerular disease (such as primary glomerular inflammation, glomerular focal sclerosis, etc.), secondary glomerulonephritis (such as with lupus nephropathy, diabetic nephropathy, etc.) and secondary infection (such as bacteria, viruses, etc.), circulatory system disease, drug poisoning, etc.Children with nephrotic syndrome basilemma early lesions is lighter, as lesions progress, a large number of protein from the eduction in urine, is one of the important reasons which reduces the plasma protein.Reduce plasma protein levels, especially albumin significantly decreased, plasma colloid osmotic pressure decline, prompting fluid in blood vessels to seep outside the blood vessels, causing the deterioration of tissue edema and effective blood volume.The mechanism of hyperlipemia nephrotic syndrome in children is not very clear.
Children with history of upper respiratory tract infections are common before the onset, mild edema, just get up in the morning, eyelid edema, the person that weigh the whole body, can light pitting edema scrotal edema performance, severe edema, ascites and pleural effusion, children often tired, anorexia, laid plaits, pale face, children immune function is low, and therefore often have infection, if not timely treatment can be combined with low blood volume shock, electrolyte disorder vascular embolization, acute renal failure and so on.Available and combination of Chinese and western medicine treatment of adrenal cortical hormone.

Upper respiratory tract infection is incentive
Children's respiratory tract infection, such as colds, tonsillitis, acute pharyngitis, if not timely and effective control of infection, after 1 ~ 4 weeks it may induce nephrotic syndrome.In general, children with nephrotic syndrome have early symptoms of infection, its outstanding characteristic is high one low, namely, highly edema and proteinuria, hypercholesterolemia and hypoalbuminemia.See more at nephrotic syndrome is minimal change disease onset age children 2 to 6 years old, and boys than girls, easy to relapse and deferment, long course of the disease.
Children because of weak physique, the immune cells in the body less than normal people, the immune function is not strong, so sometimes immune cells did not eat bugs, inclusive, but put germs germs antibody in the body and the pathogen itself combined into a kind of immune complex, as the blood circulation, the kidney, the deposit to the glomerular basement membrane, which has a damage to the kidney, make a lot of protein loss, eventually leading to nephrotic syndrome.

The classification of children with nephrotic syndrome
(1) primary nephrotic: related to the function of immune dysfunction.
Simple kidney disease - a common type, 2 ~ 7 years old.In addition to the symptoms of kidney disease, without microscopy hematuria or high blood pressure, renal biopsy by more than 90% belong to small lesions.
Children aged nephritis renal disease - 7.In addition to the symptoms of kidney disease, accompanied by microscopy hematuria, or high blood pressure, renal biopsy in addition to the small lesions, there are fertile variant, membranous proliferative and sclerosis type.
(2) secondary kidney disease secondary to malaria, mosquito bites, lupus erythematosus, allergic purpura, such as metal or drug poisoning.
(3) congenital kidney disease: a rare, begins in infancy.
Adherence to treatment is the key
Had longer duration of nephrotic syndrome and easy to break out repeatedly.To maintain a year and a half to two years of treatment.According to clinical data, some two or three children at the age of onset, the disease is not well at the age of 10 ~ 12, upper respiratory tract infection is break out repeatedly.Break out repeatedly for a long time can affect the growth and development of children, and makes the children with nephrotic syndrome treatment becomes extremely difficult.
Ill after care, to prevent a cold, children should not eat salty food and protein.The child's activity level should be strictly restricted.Children clothes don't wear too long is not change.During the treatment should not be any reduction or withdrawal.In addition, at ordinary times should pay attention to observe the child's urine, if discover the child urine color change, etc., should be timely send urine tests to the hospital.
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