Glomerular sclerosis

Etiology
1. Glomerular disease
A variety of kidney diseases, including hereditary nephritis, IgA nephropathy and non-IgA mesangial proliferative glomerulonephritis, secondary renal diseases such as diabetic nephropathy.
2. Tubular, interstitial and vascular disease
Reflux and obstructive nephropathy, acute and chronic interstitial nephritis, aristolochic acid nephropathy, systemic vasculitis, lupus nephritis.
3. Others
Polycystic kidney disease, uric acid nephropathy, hypertensive renal damage, multiple myeloma kidney damage.
Clinical manifestations
Clinical first symptom is the most common proteinuria and nephrotic syndrome, about 2/3 of patients with large amounts of proteinuria and microscopic hematuria, some gross hematuria. Can be associated with early hypertension, nocturia and impaired renal function. Most of the disease is progressive, infection, dehydration, renal damage and other factors can aggravate the progress of the disease.

an examination
1. Urine routine
In the amount of (++) proteinuria, microscopic hematuria (urinary differential microscopy prompted polymorphism), often aseptic white blood cells, urine glucose. May have renal tubular acidosis and urine concentration dilution function abnormalities.
2. Blood tests
There are hypoalbuminemia, plasma albumin less than 30 grams / liter, hyperlipidemia. Serum IgG levels decreased, most of the normal complement.
3. Renal biopsy
Pathology shows glomerular sclerosis atrophy. Uncured beads can be compensatory increase.

treatment

1. General symptomatic
Nutritional maintenance and support; lowering blood pressure lowering fat, reducing urinary protein.
2. Drugs
Under the guidance of a doctor when necessary, the use of hormones and immunosuppressive drugs to protect the kidneys toxins, prevent and delay renal damage, slow down the progression of the disease.
3. Others
Avoid complications: including anticoagulant and antithrombotic; to avoid infection; to maintain water and electrolyte and acid-base balance; to avoid and reduce adverse drug reactions. Dynamic review, according to the disease in a timely manner medicine.